Here, we studied the dose-dependent impact of regorafenib, which directly targets VEGFRs, Tie2 and PDGFR but may also have indirect inhibitory activity against signal transducer and activator of transcription 3 (STAT3), an immune-relevant target, in models of HCC with underlying liver damage.24 25. Here, STAT3 is linked to hepatocellular carcinoma.