Other broad TKIs—such as regorafenib and cabozantinib—and the anti-VEGFR2 antibody ramucirumab (in selected patients with high alpha-fetoprotein) also showed efficacy in phase III trials in patients with advanced HCC who progressed on sorafenib.6–8 Finally, the multitargeted TKI lenvatinib became a first-line therapy in advanced HCC after showing non-inferior survival compared with sorafenib.9 These successes argued for a key role of VEGF/VEGFR-driven angiogenesis in advanced HCC. This evidence concerns the gene VEGFA and hepatocellular carcinoma.