The use of a combination of the anti-VEGF antibody bevacizumab with the anti-PD-L1 antibody atezolizumab significantly increased survival outcomes over sorafenib in the randomized phase III IMBRAVE150 trial.22 Atezolizumab/bevacizumab objective response rate of 27.3%, including a 5.5% complete response rate and many durable responses, stands as a breakthrough in advanced HCC treatment. This evidence concerns the gene VEGFA and hepatocellular carcinoma.