C57BL/6 LDLr−/− mice were subjected to 5/6 nephrectomy and, at 8 weeks of age, underwent whole-body irradiation and bone marrow transplant with bone marrow from WT mice (CKD-bMPOWT) or MPO knockout mice (CKD-bMPOKO). The gene discussed is MPO; the disease is chronic kidney disease.