FABP4 and type 2 diabetes mellitus: Although the underlying mechanism of adverse LV remodelling and diastolic dysfunction in T2DM patients is complex and likely to be multifactorial, it has been proposed that circulating AFABP level reflects the accumulation of myocardial neutral lipid in T2DM patients measured by proton magnetic resonance spectroscopy and cardiac triglyceride content in obese mice assessed by lipid chromatography/mass spectrometry [47].