In fact, the cells characterized by low levels of EGFR, such as the E705 colon cancer cell line and the normal intestinal mucosa CCD 841 cell line, did not show any change in cell viability, suggesting that NEU3 is unable to hyperactivate EGFR if the receptor is present at low levels and already activated by the endogenous level of the enzyme. This evidence concerns the gene EGFR and malignant colon neoplasm.