VRK1 is highly expressed in the International Neuroblastoma Staging System (INSS) stage 4 NB compared with normal adrenal tissue, and significant differences can be observed between more aggressive neuroblastoma stages (stages 3 and 4) and more benign ones (Stages 1, 2 and 4S) (Figure 1a and Figure S1a). Here, VRK1 is linked to neuroblastoma.