Furthermore, in the MV-4-11 model, treatment with the unconjugated IL3RA-Ab TPP-9476 at 5 mg/kg, Q7D×2 showed no tumor growth inhibition (Supplementary Figure S4C,D), indicating that the antitumor activity of IL3RA-ADC is conveyed by the targeted delivery of the KSPi payload and not the IL3RA-Ab. The gene discussed is IL3RA; the disease is neoplasm.