In an in vivo setting, IL3RA-ADC administered at 10 mg/kg increased survival in both the IL3RA-positive MOLM-13 and MV-4-11 cell line-derived and IL3RA-positive AM7577 and AML11655 patient-derived AML xenograft models harboring molecular alterations associated with poor prognosis in AML. Here, IL3RA is linked to acute myeloid leukemia.