RNF20 and/or RNF40 transcript levels are depleted in a number of malignant or pre-malignant tissues, including in colonic tissue from patients with UC [21], in metastatic prostate cancer cells when compared with benign disease [123] and is lower in testicular germ cell cancer seminoma relative to normal testis [115]. This evidence concerns the gene RNF20 and Familial prostate cancer.