Chronic inflammation, such as that seen in inflammatory bowel disease (IBD) and ulcerative colitis (UC), is driven by inflammatory mediators such as nuclear factor (NF)-κB and signal transducer and activator of transcription 3 (STAT3), cytokines such as interleukin 6 (IL-6) and prostaglandins, and has been linked to an increased risk of developing cancer [106,107,108,109,110]. The gene discussed is STAT3; the disease is cancer.