Furthermore, in colorectal cancer, RNF40 has been reported to promote inflammatory signalling through NF-κB signalling [124] and in hepatocellular carcinoma, RNF40 has been shown in a large cohort (n = 130) to be almost equally expressed at high or low levels, with higher levels correlating with a worse prognosis [104]. Here, RNF40 is linked to hepatocellular carcinoma.