XIAP and cancer: Western blot analysis of the tumor tissues revealed that AIMs suppressed p-NF-κB activation and the expression of NF-κB-regulated proteins involved in cancer cell proliferation—cyclin D1 and COX-2; anti-apoptosis—Bcl-xL; invasion and migration—MMP-2 and MMP-9 (Figure 3B), but did not show a significant effect of the AIMs on anti-apoptotic protein XIAP.