In conclusion, this study suggests that AIMs have anti-cancer effects in terms of proliferation, migration, and invasion at low concentrations (10–100 μg/mL), on Hep3B human hepatocellular carcinoma cells in vitro and that the anti-cancer effects of AIMs were valid in the xenograft mouse models of Hep3B human hepatocellular carcinoma cells through the inhibition the of NF-κB and its target proteins that are involved in cancer cell proliferation, invasion, and angiogenesis. Here, NFKB1 is linked to hepatocellular carcinoma.