INS and type 1 diabetes mellitus: However, acute treatment with liraglutide for 120 min at the highest dose reduced plasma insulin level in rats with type-1 diabetes to 1.98 ± 0.72 μU/mL (n = 6), which was not significantly different (p > 0.05) from that in vehicle-treated rats (2.21 ± 0.84 μU/mL; n = 6).