Curcumin also acts as a sensitizer that increases the cytotoxicity of gefitinib and overcomes resistance in NSCLC cells with wild-type EGFR and/or KRAS mutation by induction of cell death mediated by autophagy These combination treatment effect can be reversed by pharmacological autophagy inhibitors (Baf A1 or 3-MA) or knockdown of Beclin-1 or ATG7, as well by pan-caspase inhibitor (Z-VAD-FMK) [237]. Here, EGFR is linked to non-small cell lung carcinoma.