AKT1 and cancer: Curcumin impairs the autophagic flux, as it acts as a specific chemosensitizer for cancer and, in association with 5-FU, decreases AMPK/ULK1-dependent autophagy, modulates AKT, and increases apoptosis, amplifying the antitumor effects of 5-FU in colon cancer cells [145] and in human melanoma cells [179].