al., who first sequenced the BECN1 gene (which encodes the beclin-1/ATG6 protein), followed by the discovery that a BECN1 allele is often deleted in some types cancer and that beclin-1 induces autophagy and inhibits tumor formation in human breast cancer cell line MCF-7 [23,24,25]. This evidence concerns the gene BECN1 and breast carcinoma.