GJA1 and oculodentodigital dysplasia: Since astroglial Cx43 channels actively contribute to BBB integrity, nutrient supply to neurons [92], release of gliotransmitters, propagation of intracellular Ca2+ waves, spatial K+, and glutamate buffering, it is not surprising that around 30% of ODDD patients display neurological symptoms [89], including seizures [93].