A group of 5 genes (LST1, LUC7L, MRRF, ORMDL1, SUGP2) were common in MDS cells with SF3B1, SRSF2, and U2AF1. Aberrant splicing also affected some genes mutated in MDS, for instance, STAG2 in SF3B1 and SRSF2 mutant cases and EZH2 and BCOR in SRSF2 and U2AF1 mutant cases [138]. The gene discussed is MRRF; the disease is myelodysplastic syndrome.