MPL and myelodysplastic syndrome: Levels of genes clustering in the interferon-stimulated family and signaling pathway, thrombopoietin receptor (TPOR), STAT1, and SOS1 were significantly up-regulated, while the most downregulated genes included the Wnt/β-catenin signaling pathway, B-cell receptor signaling, IL-4 signaling, and chemokine signaling such as CXCR4 which was down-regulated in almost half of patients with MDS-RS.