Broadly, the most common genes with recurrent somatic mutations in MDS include ASXL1 (10–20%), EZH2 (5–10%), NRAS (5–10%), RUNX1 (10–15%), SF3B1 (20–30%), SRSF2 (10–15%), STAG2 (5–10%), TET2 (20–30%), TP53 (10–12%), and U2AF1 (5–12%) [4,9,11,13]. The gene discussed is SF3B1; the disease is myelodysplastic syndrome.