TP53 and myelodysplastic syndrome: Several genetic mutations and inherited disorders have specifically contributed to the development of MDS in the 1st age group, including: the DNA repair FA genesset of Fanconi anemia, the GATA1/RPS19 genes precipitating Diamond Blackfan anemia, TP53 of Li-Fraumeni, SBDS gene in Shwachman-Diamond syndrome, SRP72 gene of the signal recognition particle complex, and the severe congenital neutropenia-inducing ELANE gene [120].