P2RY2 and neoplasm: Since P2Y2R is an important receptor in inflammation and fibrosis, for example in the liver [129,132], and considering that endothelial P2Y2R (activated by platelet-derived ATP) promotes leakage and tumor cells trans-endothelial migration and metastasis [133], further investigation of the role of this receptor in these TME processes in PDAC will be valuable.