Furthermore, although we demonstrated the presence of CD11b+ Gr-1+ myeloid-derived cells in the pre-metastatic lungs, which is associated with increased tumor metastasis in other cancer models [27], we did not observe any significant differences in the number of X-gal stained micro-and macro-metastases among the different treatment groups (Figure 4C). The gene discussed is ITGAM; the disease is cancer.