NFKB1 and neoplasm: Studies using cell culture models have supported some of the basic mechanisms involved in the tumour-enhancing effect of IH—the only OSA challenge directly applicable to cells—on a variety of cancer cell types originating from different organs (e.g., breast, cervical, gastric, melanoma, pancreas, lung, and colorectal), mainly showing increased tumour cell proliferation and up-regulation of HIF and NFκB activity [14,15].