When the HCC cell line SMMC-7721 was treated with conditioned medium (CM) from CAFs pretreated with high metastatic HCC-derived exosomes, they showed increases in spheroid-formation ability, motility, the expression of stemness-associated/EMT-associated genes, and resistance to sorafenib—phenomena that were partially reversed by blocking IL-6 or IL-8 using neutralizing antibodies. This evidence concerns the gene IL6 and hepatocellular carcinoma.