DSC2 and neoplasm: Through using micro-RNA profiling in U251 cells, miRNA-152-3p levels were also observed to be regulated and increased in response to Glial cell line-Derived Neurotrophic Factor, GDNF [91], which caused downregulation of Desmocollin-2 (DSC2) expression and was seen to be correlated with increased tumor grade [92,93].