In CML, miRNA-152-3p expression was elevated in bone marrow (BM) samples and upon expression of miRNA-152-3p in K562 cells, proliferation was decreased and apoptosis levels were enhanced through targeting the p27 (CDKN1B) gene [139]. This evidence concerns the gene CDKN1B and chronic myelogenous leukemia, BCR-ABL1 positive.