PIK3CA and neoplasm: Li et al. (2016) reported a decrease in expression of miRNA-152 in CRC tissues which inversely correlated with TNM staging and lymph node metastases [133], while Wang et al. (2017) observed a decrease in miRNA-152 expression in GC patients [137] and Ge et al. (2017) showed that miRNA-152-3p could target PIK3CA in BC as a tumor suppressor [132].