In the two datasets GDS1746 and GDS3289, the expression of the P2RX4 gene was significantly upregulated in the PCa samples when compared to benign prostate epithelium tissues (p < 0.0001, GDS3289, Figure 5A) or primary human prostate epithelial cell lines (p = 0.0003, GDS1746, Figure 5B). This evidence concerns the gene P2RX4 and posterior cortical atrophy.