Likewise, in severe COVID-19, various biomarkers of immune dysregulation exacerbate to a common terminal hyperinflammation indicated by robust incidence of IL-6 and lymphopenia accompanying respiratory failure, which may directly or indirectly intersect to the dysfunctional IFN- and chemokine-signaling pathways that are significantly enriched by the genetic associations [13,21,22,23,24,71,72,73,74,75]. Here, IL6 is linked to respiratory failure.