IFNA1 and COVID-19: In summary, GWAS and NGS profiling unravel the significant association of severe COVID-19 with multiple genetic errors at the gene loci enriching in IFN and chemokine signaling pathways [22,23,24,31]; however, the immuno-pathological determinants for the other major part of severe COVID-19 cases may be complicated by the interaction of the viral and especially host factors at the epigenetic levels [18,19,20,44,45,46,47,48,57].