The prevalence of auto-Abs against innate immune IFNs in life-threatening COVID-19 patients indicates an autoimmune ambient accompanied by an overwhelmed IFN response dysregulated by pathogenic DNA from massive cell death caused by the robust virus infection, which is mediated through a cyclic GMP–AMP synthase (cGAS) and signaling effector stimulator of interferon gene (STING) pathway (Figure 2) [55,56,57,58]. Here, IFNA1 is linked to COVID-19.