The current study, however, was in agreement with a previous investigation showing that circulating adipsin was negatively associated with insulin resistance, as calculated from a homeostasis model assessment of insulin resistance (HOMA-IR) [40,56], especially in participants with a BMI ≥ 25 kg/m2 or FPG ≥ 100 mg/dL [56]. This evidence concerns the gene CFD and Insulin resistance.