The serum PGE2, IL-1β, IL-6, and TNF-α levels were higher in rats with MIA induced osteoarthritis; however, these levels were suppressed in FJH-KO supplemented rats with MIA-induced osteoarthritis compared with those in rats with MIA-induced osteoarthritis (p < 0.05) (Figure 3). Here, TNF is linked to osteoarthritis.