AKT1 and osteosarcoma: For example, quinolone can be used as an AXL kinase inhibitor, which are involved in tumor cell growth [33,34]; Harmol has been used to induce cell death of human non-small cell lung cancer A549 cells [35]; nifuroxazide treatment induces apoptosis, and inhibits cell migration and invasion in osteosarcoma [36]; and Brefeldin A can regulate Bip/Akt-related autophagy in colorectal cancer cells [37].