In order to investigate whether neurons of the cerebral cortex and hippocampus severely affected in patients with AD may be vulnerable to ferroptosis, Hambright et al. [161] have shown in GPx4BIKO mice (a mice model with a conditional deletion in neurons of the forebrain of GPx4) that tamoxifen led to the deletion of GPx4 mainly in neurons of the forebrain. This evidence concerns the gene GPX4 and Alzheimer disease.