Chrysin (50 and 100 mg/kg, p.o.)showed a gastroprotective effect in the indomethacin-induced gastric ulcer model in rats, involving cytoprotective mechanisms (promoting mucus secretion), anti-inflammatory (inhibition of pro-inflammatory cytokines and macrophage mobilization), antioxidant (participation of GSH, CAT, and MDA) and angiogenic with increased expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF). The gene discussed is FGF2; the disease is gastric ulcer.