TNF and gastric ulcer: Nobiletin (5, 10, or 20 mg/kg, p.o.)and cimetidine (100 mg/kg, positive group) has protective effects on gastric ulcers induced by absolute ethanol in mice by stimulating cytoprotective PGE2, antioxidant enzymes (SOD) and negatively regulating the expression of pro-inflammatory cytokines (TNF-α and IL-6) [103].