SOD1 and ulcer disease: In summary, it was possible to observe that the flavonoids were able to protect the gastric and/or duodenal mucosa against different induction models that mimic the ulcer in men (ethanol, NSAIDs, stress and pyloric ligation), through multiple mechanisms of action such as cytoprotectors (increased mucus), antioxidants (increased activity of SOD and CAT enzymes and GSH levels), immunoregulatory (reduction in proinflammatory cytokines and increase in anti-inflammatory cytokines), antisecretory (reduction in H+) and anti-H.