HEBP1 and early-onset autosomal dominant Alzheimer disease: Even though neurons of neurodegenerative animal models and Alzheimer’s disease patients overproduce HeBP1 and are specifically more sensitive than controls to hemin-induced cell death among other death inducers [126], the actual role of heme binding to HeBP1 in the surprising enhancement of neuronal cell death and in other cellular events remains to be delineated [127].