PFS was significantly shorter in the group of TP53 mutations with AF > 60 than in the two other groups (hazard ratio (HR) 2.84, 95% confidence interval (CI) 1.48–5.48, compared to AF = 0; HR 2.19, 95% CI 1.05–4.78, compared to 0 < AF < 60) (Figure 4C). The gene discussed is TP53; the disease is atrial fibrillation.