When multivariate analysis was performed with age, gender, histology, stage, number of pathogenic mutations, presence of EGFR, KRAS, and TP53 mutations, and AF of EGFR, KRAS, and TP53 mutations to identify factors affecting PFS, the stage, number of pathogenic mutations, presence of TP53 mutations, and AF of TP53 mutations were found to be significant prognostic factors (p < 0.05). The gene discussed is KRAS; the disease is atrial fibrillation.