In co-cultures of mouse primary hepatocytes with EL-4 cells, a murine lymphoma cell line derived from a C57BL/6 mouse, we found that CITCO markedly intensified CHOP-mediated anticancer activity in EL-4 cells co-cultured with MPH from hCAR-TG mice but not from its wildtype littermates. Here, DDIT3 is linked to lymphoma.