SMAD4 and viral infectious disease: MiR-1305 and miR-587 were found to regulate the expression of TGF-β pathway members related to virus infections and lymphocytes T activation, Mothers Against DPP Family Members - SMAD3, and SMAD4) [86,87,88,89], ventricular remodeling, myocardial fibrosis and hypertrophy and, as a result, HF progression [90].