ACE2 and infection: The virus can enter into human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CMs) via ACE2, and the viral replication and cytopathic effects induce hiPSC-CM apoptosis and cessation of beating after 72 h of infection while inhibiting metabolic pathways and suppressing ACE2 expression during this initial infection stage [13].