Analysis of the ACE2 interaction network revealed 11 genes associated with virus infection-related ontological terms (ACE2, DPP4, ANPEP, CCL2, TFRC, MEP1A, ADAM17, FABP2, NPC1, CLEC4M, TMPRSS2) which could be especially affected in SARS-CoV-2 infection, leading to disturbance of the network. This evidence concerns the gene TMPRSS2 and viral infectious disease.