KDR and neoplasm: Chang et al. used anti-tumor suicide gene therapy for glioblastoma therapy on Sprague-Dawley rats using cationic VEGFR2-targeted microbubbles, complexed with luciferase gene and herpes simplex virus type 1 thymidine kinase/ganciclovir (gene suicide system) encoding plasmid DNA (pLUC and pHSV-TK/GCV).