LGALS3 and familial pancreatic carcinoma: Accordingly, loss of Galectin-3 impairs mitochondrial morphology and dynamics, leading to a more fragmented and rounded mitochondria, both in normal and cancer epithelial cells in basal conditions; on the other hand, depletion of Galectin-3 in pancreatic cancer cells was reported to be associated with increased Oxphos activity [134].