DRP1 expression levels were increased in androgen-sensitive and castration-resistant, androgen receptor-driven PC, where it favored the formation of voltage-dependent anion channels (VDAC)—mitochondrial pyruvate carrier 2 (MPC2) complex; this event boosted pyruvate transport into mitochondria, Oxphos, and lipid synthesis, supporting cell growth and proliferation [67]. The gene discussed is DNM1L; the disease is pachyonychia congenita.