In addition, MFN2 decreased the levels of phospho-phosphoinositide 3-kinase (p-PI3K), phospho-protein kinase B (p-Akt), and phospho-mammalian target of rapamycin (p-mTOR) proteins, which promote pancreatic cancer cell growth, proliferation, and metastasis [45]. This evidence concerns the gene AKT1 and familial pancreatic carcinoma.