The authors showed that DRP1 fostered (i) developing thymocytes migration and expansion, (ii) effector T-cell metabolic reprograming involving calcium/AMP-activated protein kinase (AMPK)/mTOR axis upon their activation, and (iii) migration and extravasation of T-cells, and finally avoided the shift toward a memory-like phenotype of T-cells in tumor environment. This evidence concerns the gene DNM1L and neoplasm.