Recent research work demonstrated increased OPA1 levels in ovarian cancer, together with increased mitochondrial oxidative metabolism, mitochondrial number, expression of the two master regulators of mitochondrial biogenesis, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), and mitochondrial transcription factor A (TFAM) [53]. Here, PPARGC1A is linked to ovarian carcinoma.