TP53 mutations result in three different effects that contribute to tumorigenesis: a loss-of-function (LoF) effect that deprives its tumor suppressor function, a dominant-negative (DN) effect in which the mutant allele masks the function of the wild-type allele, and a gain-of-function (GoF) effect which acquires novel oncogenic capabilities [51]. This evidence concerns the gene TP53 and neoplasm.