KNL1 and idiopathic pulmonary fibrosis: Figure 5 shows the enriched cellular functions into which the differentially expressed genes were categorized. Downregulation of cell cycle progression was found to be the most prominent change associated with curcumin treatment in IPF fibroblast (activation z-score = −1.965, q-value = 0.00125); nine genes, including ANLN, BUB1, CENPF, CIT, KLF10, KNL1, PTX3, TOP2A, and TOX, were involved in this cellular function.