Up to 25% of women diagnosed with HGSC have germline deleterious mutations in BRCA1 or BRCA2 characteristic of hereditary breast and ovarian cancer syndrome (HBOC) [4,5,6], while somatic mutations have been detected in 3–7% [7,8,9,10,11,12]. This evidence concerns the gene BRCA1 and hereditary breast ovarian cancer syndrome.