Indeed, mice had to be euthanized owing to lethal tumor burden at 8–10 weeks after injection in control Akt/NRas/pCMV mice, while only small tumor nodules could be observed until 17.5 weeks after injection in the Yap;Taz double KO (Akt/NRas/pCMV-Cre) group (Figure 5C). This evidence concerns the gene AKT1 and neoplasm.