KM estimate and LR test in the validation set showed that high expression of SNHG11 [HR(high) =1.762, 95% CI: 1.161‐2.675], CRNDE [HR(high) =1.555, 95% CI: 1.032‐2.343], MYLK‐AS1 [HR(high) =2.079, 95% CI: 1.367‐3.162], E2F3 [HR(high) =1.716, 95% CI: 1.136‐2.593], and CHEK1 [HR(high) =2.568, 95% CI: 1.677‐3.931] were risk factors for overall survival time of HCC. This evidence concerns the gene E2F3 and hepatocellular carcinoma.