E2F1 and neoplasm: For example, RPL8 participated in the immune response and promoted tumorigenesis by activating NF‐κBb;20 RPS3 acted as a tumor suppressor by activating p53, activating JNK through TRADD and cooperating with E2F1;21, 22, 23 and RPS7 played an anticancer role by activating p53, regulating PI3 K/Akt and MAPK, and stabilizing GADD45a.24, 25, 26