MiR‐199a‐5p was shown to be downregulated and acted as a suppressor of the Warburg effect in HCC by targeting a 3’‐untranslated region (UTR) of hypoxia‐inducible factor‐1α (HIF‐1α) or hexokinase 2 (HK2), thereby suppressing glucose uptake and consumption, lactate production, and cell growth and proliferation.46 This evidence concerns the gene HK2 and hepatocellular carcinoma.