Furthermore, we have previously reported two dry eye cases for which MUC5AC and MUC16 mRNA expression on the ocular surface was increased by the concomitant use of rebamipide and steroid ophthalmic suspensions, although the increase in MUC16 mRNA levels was lower than that of MUC5AC mRNA levels [44]. This evidence concerns the gene MUC16 and Keratoconjunctivitis sicca.