IFNA2 and COVID-19: Although no correlation was observed between IFN-α2a levels and disease severity or risk of death in the patients analyzed in our study, we have evidence that impaired type I IFN production or signaling may contribute to aggravate the clinical phenotype of COVID-19 in patients with monogenic errors of type I IFN-mediated immunity or with neutralizing anti–type I IFN antibodies (75, 76).