In addition, normalized IFNA2 transcripts only weakly correlated with the 28-gene type I IFN score in COVID-19 patients (Spearman’s = 0.07; P = 0.55), in contrast to their significant correlation in patients with monogenic IFNopathies (Spearman’s P = 0.57; P = 0.0015) (Figure 5E). Here, IFNA2 is linked to COVID-19.