To characterize the immunologic response in SARS-CoV-2 infection manifesting with different grades of severity, we measured the concentration of 66 biomarkers associated with monocyte/macrophage, inflammasome, NF-κB, and neutrophil activation; T cell activation and/or polarization; type I IFN and IFN response gene induction; endothelial integrity; and sepsis severity in the peripheral blood of COVID-19 patients and compared them with levels in healthy American volunteers (HVs). The gene discussed is IFNA1; the disease is COVID-19.