A statistically significant increase in sVEGFR1 levels above HVs was apparent in the most severely ill patients with COVID-19, while modest changes were observed for soluble ICAM-1 (sICAM-1) and soluble E selectin (sE selectin; also known as sCD62E) (Figure 4, Supplemental Figure 12, and Supplemental Table 3). This evidence concerns the gene ICAM1 and COVID-19.