In this study, we initially performed a comprehensive investigation of the associations between 41 differentially expressed AGs (DEAGs, Figure 1A, 1B) and HNSCC prognosis and constructed a prognosis risk model with seven AGs, including APP, CDKN2A, EGFR, HSPD1, IL2RG, PLAU and VEGFA (Figure 1C) that revealed a robust performance signature for predicting prognosis compared to clinicopathological factors in training and multiple validation sets (Figure 3). Here, JAG1 is linked to head and neck squamous cell carcinoma.