HNSCC samples with high PLAU expression contained a lower fraction of naïve B cells, CD8 T cells, CD4 memory activated T cells and follicular helper T cells compared to those with low expression, and CD4 memory resting T cells exhibited the opposite result (all P < 0.05, Figure 8B), which was consistent with the risk score. Here, CD8A is linked to head and neck squamous cell carcinoma.