METTL3 is the core methyltransferase of the m6A ‘writer’ complex and catalyzes the m6A methylation process [9]; the downregulation of this gene led to the reduction of m6A methylation in endometrial cancer [25], while its upregulation and the oncogenic role has been observed in many other forms of cancer, including ovarian [28] and breast cancers [29]. This evidence concerns the gene METTL3 and endometrial cancer.