Given that HNRNPA2B1 and HNRNPC were associated with the severity of EMs in EU samples, we selected these two molecules to evaluate their diagnostic value when compared to MKI67, CDH1 (E-cadherin), ACTA2 (α-SMA), PGR, ESR1, and ESR2, in EMs tissue samples. The gene discussed is ESR1; the disease is eosinophilia-myalgia syndrome.