Finally, high expression of YY1 was associated with relatively good OS in TCGA-KIRC patients (Figure 8E), which implied that there might be a distinct interaction relationship among BPTF, SIN3A, CNOT1 and YY1 in ccRCC patients that leads to an unclear tumor-suppressive function that promotes improved clinical outcomes. Here, SIN3A is linked to nonpapillary renal cell carcinoma.