Since the results of the survival analysis and correlation analysis between clinicopathological parameters and BPTF, SIN3A and CNOT1 in TCGA-KIRC were highly consistent, we investigated the potential mechanisms of these three chromatin-remodeling genes and their highly correlated genes (Pearson r>0.5; P<0.001) in ccRCC. The gene discussed is BPTF; the disease is nonpapillary renal cell carcinoma.