YY1 and renal cell carcinoma: Four out of the top 10 enriched pathways identified by KEGG analysis were verified by single-gene YY1 gene set enrichment analysis (GSEA), the TGF-beta signaling pathway, the Wnt signaling pathway, RCC and ubiquitin-mediated proteolysis (Supplementary Figure 2B); these results were consistent with the enrichment results for the intersected genes (Supplementary Figure 2A), which could be considered additional evidence supporting YY1 as the potential transcriptional factor due to the similar pathway annotations.