SHC1 and nonpapillary renal cell carcinoma: In patients with ccRCC, many of these substrates have been identified as poor prognostic factors, such as: JAK2 [48], JAK3 [49], CSK [50], RET [51], AR [52], AHR [53, 54], IRF4 [55], SHC1 [56], TGFBR2 [57].