The data of univariate analysis showed that ARHGEF39 expression (HR 1.561, 95% CI: 1.155-2.110, p = 0.004), age (HR 1.781, 95% CI: 1.300-2.439, p = 0.000), tumor grade (HR 2.668, 95% CI: 1.893-3.759, p = 0.000), clinical-stage (HR 3.850, 95% CI: 2.802-5.291, p = 0.000), Pathologic-T (HR 3.152, 95% CI: 2.326-4.272, p = 0.000), Pathologic-M (HR 4.323, 95% CI: 3.163-5.908, p = 0.000) and Pathologic-N (HR 3.411, 95% CI: 1.810-6.428, p = 0.000) were considered to be the prognostic factors that correlated with the overall survival of ccRCC patients. The gene discussed is ARHGEF39; the disease is neoplasm.