To investigate whether LINC01126/HIF‐1α aggravates periodontitis development via accelerated MAPK pathway, we first use the Western blot to measure the protein expression of the total p38, ERK1/2, and JNK in sh‐HIF‐1α, pCDH‐01126/HIF‐1α‐treated hPDLCs. The gene discussed is MAPK3; the disease is periodontitis.