In the present study, we found that the age of onset of xmrk-induced tumorigenesis (hyperpigmentation and malignant tumor) in the Hd-rR or hybrid strain model did not depend on the p53 status but rather, quantification of the tumorigenesis process revealed that the frequency of hyperpigmentation and tumors is proportional to the p53 status. Here, TP53 is linked to cancer.