Vascular endothelial growth factor (VEGF), the major regulator in tumor angiogenesis, contributed to immune escape via blocking DC differentiation, inhibiting T‐cell development and reducing its infiltration, inducing Tregs and MDSCs et al.91, 92In IMpower150,17 the addition of atezolizumab to bevacizumab and chemotherapy significantly prolonged OS in patients with advanced nonsquamous NSCLC. This evidence concerns the gene VEGFA and non-small cell lung carcinoma.