The interaction of VEGF and VEGFR resulted in the activation of the VEGF signaling pathway that promotes tumor angiogenesis by inducing proliferation, sprouting, and migration of TECs and by increasing the microvascular permeability (Lakshmikanthan et al. 2018; Melincovici et al. 2018; Peach et al. 2018). This evidence concerns the gene VEGFA and neoplasm.