Based on genetic analysis, TAMs can produce various molecules, including VEGF, TNF-α, IL-1β, IL-8, platelet-derived growth factor (PDGF), thymidine phosphorylase, and MMPs that are involved in tumor angiogenesis (Qian and Pollard 2010; Goswami et al. 2017; Fu et al. 2020). This evidence concerns the gene IL1B and neoplasm.