We showed that miR-4721 is induced by EBV-miR-BART22 through the PI3K/AKT/c-JUN/Sp1 signaling axis to target GSK3β, which activates the β-catenin-stimulated cell cycle signal and thus enhance the tumorigenic capacity of NPC (Figure S2C). Here, SP1 is linked to nasopharyngeal carcinoma.