After 15 days, mice injected with SUNE1-miR-4721 or HONE1-miR-4721 had higher tumor burdens (Figure 2E) and displayed elevated Ki-67 and proliferating cell nuclear antigen (PCNA) expression in the overexpressed (oe-)miR-4721 group relative to the negative control (Figure 2F). The gene discussed is MKI67; the disease is neoplasm.