SP1 and nasopharyngeal carcinoma: The relative fold enrichment of IP-SP1 was 0.061 in the oe-c-JUN group and 0.008 in the NC group (Figure 6G, p < 0.001), which demonstrated that c-JUN facilitates the transcriptional activity of Sp1. Also, c-JUN expression was positively related to miR-4721 expression in NPC cells (Figure 6H; Figure S1E).