EGFR and colorectal cancer: ciRS-7 was also reported to be overexpressed in colorectal cancer by Weng et al.,46 promoting aggressiveness by downregulating miR-7 by sponging activity and interfering in the suppression of the epidermal growth factor receptor (EGFR)/RAF1/mitogen-activated protein kinase (MAPK) pathway and increasing the probability for metastasis.