CDH2 and cancer: We also document that SPAG5 ectopic expression confers upon untransformed MCF-10A breast cells the ability to form colonies, and, concordantly, SPAG5 depletion markedly reduces proliferation, clonogenicity, and cancer cell migration, as well as affects the main EMT markers, such as vimentin and N cadherin (Fig. 3H, I and Supplementary Fig. 3H, I).