SPAG5 and breast cancer: Of note, treatment of MDA-MB-231 breast cancer cells and MCF-10A cells stably overexpressing SPAG5 with Dasatinib and Verteporfin reduced SPAG5 protein level in a dose-dependent manner (Fig. 6I, J lower panel and Supplementary Fig. 6L, N, O) and affected their respective colony-forming ability (Supplementary Fig. 6K–M).