Interestingly, SPAG5’s expression is higher (ANOVA test P = 1.3655e−94 and ANOVA test P = 1.3655e−94) in the Luminal B, HER2, and basal-like breast cancer subtypes, as compared to the Luminal A subtype (Fig. 1E, F). The gene discussed is ERBB2; the disease is breast cancer.