CD8A and neoplasm: Sethi et al. demonstrated that Th1 (IFNγ+CD4+CD3+) and Tc1(IFNγ+CD8+CD3+) cells in the TME were increased, and pro-tumor IL17a (IL17a+CD3+) and IL10 (IL10+CD4+CD3+) were decreased after gut microbiome depletion by oral antibiotics29.