ERICH3 and depressive symptom measurement: We also found that the ERICH3 rs10580409 nsSNP which was identified in our GWAS for plasma 5-HT concentrations in MDD patients, was also directly associated with SSRI response in independent SSRI treatment response GWAS [15], including those for the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) [4] and the International SSRI Pharmacogenomics Consortium (ISPC) [9].