ERICH3 and major depressive disorder: In addition to the ERICH3 nsSNP that we found to be associated with plasma 5-HT concentrations and SSRI response in MDD patients [15], another ERICH3 SNP, rs114396406, has recently been associated with several depression-related phenotypes including risk for severe depression (P = 9.362E-05; OR = 0.926; N = 54,567), in a large cohort GWAS reported by the Global Biobank Engine using the UK Biobank dataset [25] (https://gbe.stanford.edu/).